Synthesis and Biological Evaluation of Coumarin Derivatives as Inhibitors of Mycobacterium bovis (BCG)

Authors

  • Ali Hossein Rezayan,

    1. Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Tehran, Iran
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  • Parisa Azerang,

    1. Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute, Tehran, Iran
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  • Soroush Sardari,

    Corresponding author
    1. Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute, Tehran, Iran
      Corresponding author: Soroush Sardari,ssardari@hotmail.com; sardari@pasteur.ac.ir
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  • Afshin Sarvary

    1. Department of Chemistry, Faculty of Basic Science, Babol University of Technology, Babol, Iran
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Corresponding author: Soroush Sardari,ssardari@hotmail.com; sardari@pasteur.ac.ir

Abstract

The coumarin compounds are an important class of biologically active molecules, which have attractive caught the attention of many organic and medicinal chemists, due to potential pharmaceutical implications and industrial applications. We herein report the one-pot procedure for the efficient synthesis of coumarin derivatives using commercially available substrates via isocyanide-based multicomponent condensation reactions. These compounds were evaluated for anti-mycobacterium activity against Mycobacterium bovis (Bacillus Calmette–Guerin). The preliminary results indicated that all of the tested compounds showed relatively good activity against the test organism. The compounds 7e, 7l, and 7m showed high anti-tuberculosis activity.

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