These authors contributed equally to this paper.
Study of Chemical Ligation Via 17-, 18- and 19-Membered Cyclic Transition States
Article first published online: 25 OCT 2012
© 2012 John Wiley & Sons A/S
Chemical Biology & Drug Design
Volume 80, Issue 6, pages 821–827, December 2012
How to Cite
Panda, S. S., El-Nachef, C., Bajaj, K., Al-Youbi, A. O., Oliferenko, A. and Katritzky, A. R. (2012), Study of Chemical Ligation Via 17-, 18- and 19-Membered Cyclic Transition States. Chemical Biology & Drug Design, 80: 821–827. doi: 10.1111/cbdd.12053
- Issue published online: 25 OCT 2012
- Article first published online: 25 OCT 2012
- Accepted manuscript online: 13 SEP 2012 11:23PM EST
- Received 30 January 2012, revised 10 August 2012 and accepted for publication 17 August 2012
- acyl migration;
- molecular modeling;
Unprotected S-acylated cysteine isopeptides containing α-, β- or γ-amino acid units have been synthesized, and their conversion to native hexapeptides by S- to the N-terminus ligations involving 17-, 18- and 19-membered cyclic transition states have been demonstrated both experimentally and computationally to be more favorable than intermolecular cross-ligations.