Chemotherapy Drugs Form Ion Pores in Membranes Due to Physical Interactions with Lipids
Article first published online: 25 OCT 2012
© 2012 John Wiley & Sons A/S
Chemical Biology & Drug Design
Volume 80, Issue 6, pages 992–1002, December 2012
How to Cite
Ashrafuzzaman, M., Tseng, C.-Y., Duszyk, M. and Tuszynski, J. A. (2012), Chemotherapy Drugs Form Ion Pores in Membranes Due to Physical Interactions with Lipids. Chemical Biology & Drug Design, 80: 992–1002. doi: 10.1111/cbdd.12060
- Issue published online: 25 OCT 2012
- Article first published online: 25 OCT 2012
- Accepted manuscript online: 24 SEP 2012 09:18PM EST
- Received 26 March 2012, revised 5 September 2012 and accepted for publication 8 September 2012
Figure S1. Structures of TCC and TXL (Taxol-A).
Figure S2. (A) TCC and TXL (both at 90 μM) permeabilize lipid bilayer membranes by inducing nonzero current events. (B) A recorded 60 seconds current trace across a lipid bilayer membrane before being doped with any CD.
Figure S3. Activity A increases in proportion to V and cD. A = ∑Ai/(∑Ai + Anc), Ai and Anc are total point counts in the conducting phase i and the nonconducting phase, respectively.
Figure S4. TCC pore activity A is independent of the pH of the membrane bathing aqueous phase.
|CBDD_12060_sm_FigS1.tif||7079K||Supporting info item|
|CBDD_12060_sm_FigS2a.tif||7079K||Supporting info item|
|CBDD_12060_sm_FigS2b.tif||7079K||Supporting info item|
|CBDD_12060_sm_FigS3.tif||1894K||Supporting info item|
|CBDD_12060_sm_FigS4.tif||1894K||Supporting info item|
|CBDD_12060_sm_legends.docx||11K||Supporting info item|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.