Figure S1. Structures of TCC and TXL (Taxol-A).

Figure S2. (A) TCC and TXL (both at 90 μM) permeabilize lipid bilayer membranes by inducing nonzero current events. (B) A recorded 60 seconds current trace across a lipid bilayer membrane before being doped with any CD.

Figure S3. Activity A increases in proportion to V and cD. A = ∑Ai/(∑Ai +  Anc), Ai and Anc are total point counts in the conducting phase i and the nonconducting phase, respectively.

Figure S4. TCC pore activity A is independent of the pH of the membrane bathing aqueous phase.

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