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Keywords:

  • aryl;
  • heteroaryl;
  • modafinil;
  • transporters;
  • wake-promoting agents

In search of a next generation molecule to the novel wake-promoting agent modafinil, a series of aryl-heteroayl-derived wakefulness enhancing agents (in rats) was developed. From this work, compound 16 was separated into its enantiomers to profile them individually.