Ming Zheng and Youguang Zheng contributed equally to this work.
Synthesis and Quantum Chemical Studies of New 4-aminoquinazoline Derivatives as Aurora A/B Kinase Inhibitors
Article first published online: 26 DEC 2012
© 2012 John Wiley & Sons A/S
Chemical Biology & Drug Design
Volume 81, Issue 3, pages 399–407, March 2013
How to Cite
Zheng, M., Zheng, Y., Xue, Y., Liu, Y., An, L., Zhang, L., Ji, M., Xue, B., Wu, X., Gong, X., Gu, N. and Zhan, X. (2013), Synthesis and Quantum Chemical Studies of New 4-aminoquinazoline Derivatives as Aurora A/B Kinase Inhibitors. Chemical Biology & Drug Design, 81: 399–407. doi: 10.1111/cbdd.12089
- Issue published online: 13 FEB 2013
- Article first published online: 26 DEC 2012
- Received 30 July 2012, revised 7 October 2012 and accepted for publication 2 November 2012
- anti-proliferative activity;
- Aurora A and B;
- quantum chemistry
Nine novel 4-aminoquinazoline derivatives were designed and synthesized. Biochemical and cellular analyses demonstrated that most of the derivatives exhibited a strong activity to inhibit Aurora A and B kinases and to suppress the proliferation of a panel of human tumor cell lines (U937, K562, A549, LoVo, and HT29). Quantum chemical studies were also carried out to determine the structural features of these compounds engaged in the inhibition of Aurora kinases.