1,3,4-Thiadiazole and its Derivatives: A Review on Recent Progress in Biological Activities

Authors

  • Abhishek Kumar Jain,

    Corresponding author
    • Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradhesh, India
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  • Simant Sharma,

    1. Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradhesh, India
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  • Ankur Vaidya,

    1. Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradhesh, India
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  • Veerasamy Ravichandran,

    1. Faculty of Pharmacy, AIMST University, Semeling, Kedah, Malaysia
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  • Ram Kishore Agrawal

    Corresponding author
    • Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradhesh, India
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Corresponding authors: Abhishek Kumar Jain, abhishekjain2105@rediffmail.com; and Ram Kishore Agrawal, ramkishoreagrawal@gmail.com

Abstract

The 1,3,4-thiadiazole nucleus is one of the most important and well-known heterocyclic nuclei, which is a common and integral feature of a variety of natural products and medicinal agents. Thiadiazole nucleus is present as a core structural component in an array of drug categories such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antineoplastic, and antitubercular agents. The broad and potent activity of thiadiazole and their derivatives has established them as pharmacologically significant scaffolds. In this study, an attempt has been made with recent research findings on this nucleus, to review the structural modifications on different thiadiazole derivatives for various pharmacological activities.

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