Rationally Designed Sulfamides as Glutamate Carboxypeptidase II Inhibitors
Version of Record online: 25 SEP 2013
© 2013 John Wiley & Sons A/S
Chemical Biology & Drug Design
Volume 82, Issue 5, pages 612–619, November 2013
How to Cite
Choy, C. J., Fulton, M. D., Davis, A. L., Hopkins, M., Choi, J. K., Anderson, M. O. and Berkman, C. E. (2013), Rationally Designed Sulfamides as Glutamate Carboxypeptidase II Inhibitors. Chemical Biology & Drug Design, 82: 612–619. doi: 10.1111/cbdd.12174
- Issue online: 16 OCT 2013
- Version of Record online: 25 SEP 2013
- Accepted manuscript online: 17 JUN 2013 06:26AM EST
- Manuscript Accepted: 28 MAY 2013
- Manuscript Revised: 7 MAY 2013
- Manuscript Received: 3 JAN 2013
|cbdd12174-sup-0001-FigS1.tif||image/tif||743K||Figure S1 Un-restrained computational docking of compound 2d into the active site of an X-ray crystal structure of GCP2 (PDB = 3D7H).|
|cbdd12174-sup-0002-FigS2.tif||image/tif||255K||Figure S2 Un-restrained computational docking of compound 2e into the active site of an X-ray crystal structure of GCP2 (PDB = 3D7H).|
|cbdd12174-sup-0003-FigS3.tif||image/tif||3427K||Figure S3 Representation of docked compound 2d (red) superimposed with 2e (blue).|
|cbdd12174-sup-0004-FigS4.tif||image/tif||3152K||Figure S4 Un-restrained computational docking of compound 2f into the active site of an X-ray crystal structure of GCP2 (PDB = 3D7H).|
Table S1 Interactions between ligands 2d–2f, and the GCP2 active site residues, as determined by computational docking.
Scheme S1 Synthesis of 6b and 6c. Reagents and conditions: (a) HBTU, TEA, Benzoic acid, DMF; (b) 4 m HCl in Dioxane.
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