Crystallographic Fragment-Based Drug Discovery: Use of a Brominated Fragment Library Targeting HIV Protease
Version of Record online: 30 OCT 2013
© 2013 John Wiley & Sons A/S
Chemical Biology & Drug Design
Volume 83, Issue 2, pages 141–148, February 2014
How to Cite
Tiefenbrunn, T., Forli, S., Happer, M., Gonzalez, A., Tsai, Y., Soltis, M., Elder, J. H., Olson, A. J. and Stout, C. D. (2014), Crystallographic Fragment-Based Drug Discovery: Use of a Brominated Fragment Library Targeting HIV Protease. Chemical Biology & Drug Design, 83: 141–148. doi: 10.1111/cbdd.12227
- Issue online: 17 JAN 2014
- Version of Record online: 30 OCT 2013
- Accepted manuscript online: 2 SEP 2013 09:54AM EST
- Manuscript Accepted: 12 AUG 2013
- Manuscript Revised: 1 AUG 2013
- Manuscript Received: 14 MAY 2013
- National Institutes of Health and National Institute for General Medical Sciences. Grant Number: P01 GM083658-05
- Molecular Basis of Viral Pathogenesis Training Grant. Grant Number: 2T32AI007354
- DOE Office of Biological and Environmental Research, National Institutes of Health, National Institute of General Medical Sciences. Grant Number: P41GM103393
- National Center for Research Resources. Grant Number: P41RR001209
- Program Project
- Program Project Grant
Figure S1. Interactions of Br15 at the crystal interface.
Figure S2. Interactions of Br22 at the crystal interface.
Figure S3. Interactions of Br27 at the crystal interface.
Table S1. Brominated fragment structures, Maybridge catalog number, concentration, data resolution, and binding sites.
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