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Keywords:

  • stapled peptides;
  • α-helix;
  • ring-closing metathesis

We have previously shown that the incorporation of an 8-atom all-hydrocarbon ‘staple’ at positions i and + 3 of a synthetic peptide results in substantial stabilization of the α-helical conformation. As part of our ongoing effort to explore the scope and utility of all-hydrocarbon stapling systems, we have investigated and report herein the properties of a new i,+ 3 stapling system that employs a 6-carbon cross-link.