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Figure S1. Distribution of consensus sites (CSs) identified in the X-ray structure of the M2 receptor (PDB ID: 3UON) through FTMAP analysis.

Figure S2. Distribution of consensus sites (CSs) in the simulation-derived inactive (green), intermediate 1 (orange), intermediate 2 (cyan) and active (red) conformers of the M2 receptor.

Figure S3. Key residue structural changes are identified in allosteric Site 2 during the aMD simulation.

Figure S4. Key residue structural changes are identified in Site 5 during the aMD simulation.

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