A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery
Article first published online: 13 MAY 2014
© 2014 The Authors. Chemical Biology & Drug Design Published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Chemical Biology & Drug Design
Volume 84, Issue 1, pages 24–35, July 2014
How to Cite
Gooding, M., Adigbli, D., Edith Chan, A. W., Melander, R. J., MacRobert, A. J. and Selwood, D. L. (2014), A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery. Chemical Biology & Drug Design, 84: 24–35. doi: 10.1111/cbdd.12295
- Issue published online: 19 JUN 2014
- Article first published online: 13 MAY 2014
- Accepted manuscript online: 28 JAN 2014 08:05AM EST
- Manuscript Accepted: 22 JAN 2014
- Manuscript Revised: 8 JAN 2014
- Manuscript Received: 7 JUN 2013
- Association for International Cancer Research. Grant Number: 06-0076
- biophysical chemistry;
- chemical biology;
- nucleic acid;
- RNAi and antisense techniques
A wider application of siRNA- and miRNA- based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier (SMoC) system for siRNA modeled to interact with cell surface proteoglycans. This bifurcated SMoC has similar affinity for the model proteoglycan heparin to an equivalent polyarginine peptide and exhibits significant mRNA knockdown of protein levels comparable to lipofectamine and the previously reported linear SMoC.