Molecular Modeling of a Phenyl-Amidine Class of NMDA Receptor Antagonists and the Rational Design of New Triazolyl-Amidine Derivatives (pages 185–197)
Paula A. Abreu, Helena C. Castro, Roberto Paes-de-Carvalho, Carlos R. Rodrigues, Viveca Giongo, Izabel C. N. P. Paixão, Marcos V. Santana, Jainne M. Ferreira, Octavia M. Caversan, Raquel A. C. Leão, Luana M. S. Marins, André M. Henriques, Florence M. C. Farias, Magaly G. Albuquerque and Sergio Pinheiro
Article first published online: 17 DEC 2012 | DOI: 10.1111/cbdd.12056
We performed a QSAR analysis of 17 phenyl-amidines described as NMDA receptor antagonists, and designed new triazolyl-amidines. Combination of synthetic chemistry, biological assays and molecular modeling studies is presented.