Does Aluminium Bind to Histidine? An NMR Investigation of Amyloid β12 and Amyloid β16 Fragments (pages 48–59)
Priya Narayan, Bankala Krishnarjuna, Vinaya Vishwanathan, Dasappa Jagadeesh Kumar, Sudhir Babu, Krishna Venkatachala Ramanathan, Kalpathy Ramaier Katchap Easwaran, Holenarasipur GunduRao Nagendra and Srinivasarao Raghothama
Article first published online: 21 JUN 2013 | DOI: 10.1111/cbdd.12129
NMR studies reveal non-histidine binding site for aluminium in N-terminal fragments (Aβ12 and Aβ16) of amyloid-beta peptide implicated in Alzheimer disease. Structure similarity is maintained between the two fragments and the aluminium metal binding site is unaltered in the presence and absence of His13 and His14.