Penetratin and Derivatives Acting as Antibacterial Agents (pages 167–177)
Adriana D. Garro, Mónica S. Olivella, José A. Bombasaro, Beatriz Lima, Alejandro Tapia, Gabriela Feresin, Andras Perczel, Csaba Somlai, Botond Penke, Javier López Cascales, Ana M. Rodríguez and Ricardo D. Enriz
Version of Record online: 1 JUL 2013 | DOI: 10.1111/cbdd.12143
In this study we report the synthesis, in vitro evaluation, and conformational study of penetratin and structurally related derivatives acting as antibacterial agents. Among the compounds evaluated two methionine sulfoxide derivatives (RQIKIWFQNRRM[O] KWKK-NH2 and RQIKIFFQNRRM[O]KFKK-NH2) and a nonapeptide (RQIRRWWQR-NH2) exhibited the strongest antibacterial effect against the Gram-negative and Gram-positive bacteria tested in this study.