Assessment of Leishmanicidal and Trypanocidal Activities of Aliphatic Diamine Derivatives (pages 697–704)
Celina N. Yamanaka, Raquel B. Giordani, Celso O. Rezende Jr, Iriane Eger, Rafael L. Kessler, Maiko L. Tonini, Milene H. de Moraes, Debora P. Araújo, Jose A. Zuanazzi, Mauro V. de Almeida and Mario Steindel
Article first published online: 10 AUG 2013 | DOI: 10.1111/cbdd.12191
Two novel lipophilic diamines with potent and selective leishmanicidal and trypanocidal activity are described. N-tetradecyl-1,4-butanediamine killed intracellular forms of Leishmania braziliensis and Leishmania chagasi in low micromolar concentrations. N-decyl-1,6-hexanediamine was six times more effective than the reference drug Benznidazole against T. cruzi amastigotes. These compounds are promising lead molecules for the development of new drugs against protozoan diseases.