Synthesis of Isosteric Triterpenoid Derivatives and Antifungal Activity (pages 344–349)
Adrine Innocente, Bruna B. Casanova, Fernanda Klein, Aline D. Lana, Dariane Pereira, Mauro N. Muniz, Pascal Sonnet, Grace Gosmann, Alexandre M. Fuentefria and Simone C. B. Gnoatto
Article first published online: 1 FEB 2014 | DOI: 10.1111/cbdd.12251
Six compounds were synthesised and tested against eleven mucocutaneous and cutaneous mycotic agents. Two active compounds were identified. The MIC values of the derivatives of ursolic and betulinic acids were in the range of 16–32 µg/mL and 4–16 µg/mL, respectively, whereas fungicidal effects were observed at concentrations ranging from 16 to 128 µg/mL and 8 to 128 µg/mL, respectively.