High-Throughput Screen of Natural Product Extracts in A Yeast Model of Polyglutamine Proteotoxicity (pages 440–449)
Gladis M. Walter, Avi Raveh, Sue-Ann Mok, Thomas J. McQuade, Carl J. Arevang, Pamela J. Schultz, Matthew C. Smith, Samuel Asare, Patricia G. Cruz, Susanne Wisen, Teatulohi Matainaho, David H. Sherman and Jason E. Gestwicki
Article first published online: 18 MAR 2014 | DOI: 10.1111/cbdd.12259
A ‘live-dead’ assay for polyQ toxicity was developed and miniaturized for 384-well format. Activators of a stress response were identified as anti-polyQ compounds by screening a pre-fractionated natural product collection.