Folic Acid-Conjugated 4-Amino-Phenylboronate, a Boron-Containing Compound Designed for Boron Neutron Capture Therapy, is an Unexpected Agonist for Human Neutrophils and Platelets (pages 532–540)
Cesare Achilli, Sushilkumar A. Jadhav, Gianni F. Guidetti, Annarita Ciana, Vittorio Abbonante, Alessandro Malara, Maurizio Fagnoni, Mauro Torti, Alessandra Balduini, Cesare Balduini and Giampaolo Minetti
Version of Record online: 18 MAR 2014 | DOI: 10.1111/cbdd.12264
4-amino-phenylboronate conjugated with folic acid is a possible compound for selective delivery of 10B in boron neutron capture therapy. Its biocompatibility with blood cells was tested. It was completely inert toward erythrocytes, whereas it induced platelet aggregation, neutrophil oxidative burst, and inhibition of platelet progenitor (megakaryocyte) development. Folic acid and 4-amino-phenylboronate are each essentially inert toward blood cells. A new property, which was not present in either of the reactants, appeared in the adduct.