Targeting Dormant Tuberculosis Bacilli: Results for Molecules with a Novel Pyrimidone Scaffold (pages 201–207)
Rohit R. Joshi, Avinash Barchha, Vijay M. Khedkar, Raghuvir R. S. Pissurlenkar, Sampa Sarkar, Dhiman Sarkar, Rohini R. Joshi, Ramesh A. Joshi, Anamik K. Shah and Evans C. Coutinho
Article first published online: 12 JUL 2014 | DOI: 10.1111/cbdd.12373
This paper reports the second molecule after TMC-207, with the ability to inhibit tuberculosis bacilli in its dormant phase. The paper reports molecules with a novel Pyrimidone Scaffold, the synthesis of which was accomplished with a modified multi-component Biginelli reaction. A classification model was generated using recursive partitioning (RP) technique to identify structural characteristics of the molecules with their varying activities.