A Fluorescent Probe for Imaging p53–MDM2 Protein–Protein Interaction (pages 411–417)
Zhenzhen Liu, Zhenyuan Miao, Jin Li, Kun Fang, Chunlin Zhuang, Lupei Du, Chunquan Sheng and Minyong Li
Article first published online: 10 OCT 2014 | DOI: 10.1111/cbdd.12434
A novel small-molecule fluorescent probe was developed to detect and image the p53–MDM2 interaction based on an environment-sensitive fluorophore, N,N-dimethyl-1,8-naphthalimide. After extensive biological examination, this probe L1 exhibited practical activity and selectivity in vitro and in cellulo.