Discovery of neurotrophic agents based on hydroxycinnamic acid scaffold (pages 926–937)
Razieh Hosseini, Fatemeh Moosavi, Hamid Rajaian, Tiago Silva, Diogo Magalhães e Silva, Pedro Soares, Luciano Saso, Najmeh Edraki, Ramin Miri, Fernanda Borges and Omidreza Firuzi
Version of Record online: 9 SEP 2016 | DOI: 10.1111/cbdd.12829
In this study, the neurotrophic capacity of hydroxycinnamic acids and their alkyl esters was examined. Our findings demonstrate that alkyl esters of caffeic acid possess strong neurotrophic effects, especially decyl and dodecyl caffeate, which significantly promoted neuronal survival. Propyl and butyl caffeate esters could also significantly enhance NGF-induced neurite outgrowth. The findings of the docking study suggested phosphatidylinositol 3-kinase (PI3K) as the potential molecular target. In conclusion, esters of caffeic acid could be potentially useful for discovery of therapeutic agents for neurodegenerative diseases.