We thank Dr. George Mias for his helpful comments on the manuscript.
SPECIAL SECTION: GENOMICS
Child Development and Structural Variation in the Human Genome
Version of Record online: 13 JAN 2013
© 2013 The Authors. Child Development © 2013 Society for Research in Child Development, Inc.
Volume 84, Issue 1, pages 34–48, January/February 2013
How to Cite
Zhang, Y., Haraksingh, R., Grubert, F., Abyzov, A., Gerstein, M., Weissman, S. and Urban, A. E. (2013), Child Development and Structural Variation in the Human Genome. Child Development, 84: 34–48. doi: 10.1111/cdev.12051
- Issue online: 25 JAN 2013
- Version of Record online: 13 JAN 2013
Structural variation of the human genome sequence is the insertion, deletion, or rearrangement of stretches of DNA sequence sized from around 1,000 to millions of base pairs. Over the past few years, structural variation has been shown to be far more common in human genomes than previously thought. Very little is currently known about the effects of structural variation on normal child development, but such effects could be of considerable significance. This review provides an overview of the phenomenon of structural variation in the human genome sequence, describing the novel genomics technologies that are revolutionizing the way structural variation is studied and giving examples of genomic structural variations that affect child development.