Ion channels regulating mast cell biology
Article first published online: 22 APR 2013
© 2012 Blackwell Publishing Ltd
Clinical & Experimental Allergy
Volume 43, Issue 5, pages 491–502, May 2013
How to Cite
Clinical & Experimental Allergy, 2013 (43) 491–503., .
- Issue published online: 22 APR 2013
- Article first published online: 22 APR 2013
- Accepted manuscript online: 16 OCT 2012 11:00AM EST
- Manuscript Accepted: 28 AUG 2012
- Manuscript Revised: 6 JUL 2012
- Manuscript Received: 20 APR 2012
Mast cells play a central role in the pathophysiology of asthma and related allergic conditions. Mast cell activation leads to the degranulation of preformed mediators such as histamine and the secretion of newly synthesised proinflammatory mediators such as leukotrienes and cytokines. Excess release of these mediators contributes to allergic disease states. An influx of extracellular Ca2+ is essential for mast cell mediator release. From the Ca2+ channels that mediate this influx, to the K+, Cl− and transient receptor potential channels that set the cell membrane potential and regulate Ca2+ influx, ion channels play a critical role in mast cell biology. In this review we provide an overview of our current knowledge of ion channel expression and function in mast cells with an emphasis on how channels interact to regulate Ca2+ signalling.