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Ion channels regulating mast cell biology

Authors

  • I. Ashmole,

    1. Department of Infection, Immunity and Inflammation, Institute for Lung Heath, Glenfield Hospital, University of Leicester, Leicester, LE3 9QP, UK
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  • P. Bradding

    Corresponding author
    • Department of Infection, Immunity and Inflammation, Institute for Lung Heath, Glenfield Hospital, University of Leicester, Leicester, LE3 9QP, UK
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Correspondence:

Peter Bradding, Department of Respiratory Medicine, Glenfield Hospital, Groby Rd, Leicester, LE3 9QP,UK. E-mail: pbradding@hotmail.com

Summary

Mast cells play a central role in the pathophysiology of asthma and related allergic conditions. Mast cell activation leads to the degranulation of preformed mediators such as histamine and the secretion of newly synthesised proinflammatory mediators such as leukotrienes and cytokines. Excess release of these mediators contributes to allergic disease states. An influx of extracellular Ca2+ is essential for mast cell mediator release. From the Ca2+ channels that mediate this influx, to the K+, Cl and transient receptor potential channels that set the cell membrane potential and regulate Ca2+ influx, ion channels play a critical role in mast cell biology. In this review we provide an overview of our current knowledge of ion channel expression and function in mast cells with an emphasis on how channels interact to regulate Ca2+ signalling.

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