Clinical & Experimental Allergy

Role of CCL18 in asthma and lung immunity

Authors

  • A. Tsicopoulos,

    Corresponding author
    1. Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
    2. CNRS UMR 8204, Lille, France
    3. Univ Lille Nord de France, Lille, France
    4. Clinique des Maladies Respiratoires et Centre Hospitalier Régional et Universitaire de Lille, Lille, France
    • Pulmonary Immunity, Institut National de la Santé Et de la Recherche Médicale, Lille, France
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  • Y. Chang,

    1. Pulmonary Immunity, Institut National de la Santé Et de la Recherche Médicale, Lille, France
    2. Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
    3. CNRS UMR 8204, Lille, France
    4. Univ Lille Nord de France, Lille, France
    5. Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada
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  • S. Ait Yahia,

    1. Pulmonary Immunity, Institut National de la Santé Et de la Recherche Médicale, Lille, France
    2. Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
    3. CNRS UMR 8204, Lille, France
    4. Univ Lille Nord de France, Lille, France
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  • P. de Nadai,

    1. Pulmonary Immunity, Institut National de la Santé Et de la Recherche Médicale, Lille, France
    2. Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
    3. CNRS UMR 8204, Lille, France
    4. Univ Lille Nord de France, Lille, France
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  • C. Chenivesse

    1. Pulmonary Immunity, Institut National de la Santé Et de la Recherche Médicale, Lille, France
    2. Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
    3. CNRS UMR 8204, Lille, France
    4. Univ Lille Nord de France, Lille, France
    5. Service de Pneumologie et Reanimation, Groupe hospitalier Pitié-Salpêtrière, Paris, France
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Correspondence:

Anne Tsicopoulos, Centre for Infection and Immunity of Lille, Pulmonary Immunity, Institut Pasteur de Lille, 1 rue du Prof. Calmette, B.P. 245, 59 019 Lille, France.

E-mail: anne.tsicopoulos@pasteur-lille.fr

Summary

Allergic asthma is a prototypic Th2 mediated disease, where chemokines orchestrate the inflammatory cell recruitment. Most chemokines have a pro-inflammatory role. In this review, we focus on the potential role, in asthma and lung immunity, of CCL18 a chemokine both constitutively expressed at high levels in the lung and induced in inflammatory conditions. This chemokine is mainly produced by antigen presenting cells, and induced by Th2 type cytokines. The available data suggest that this chemokine may exhibit dual functions, with both pro- and anti-inflammatory properties, the latter through its ability to generate adaptive regulatory T cells in healthy subjects, with a loss of function in allergic patients. However, the functional implications are at the moment hampered by the lack of data on the nature of its putative receptor, and the absence of murine orthologue.

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