cea12076-sup-0001-FigS1.tifimage/tif572KFigure S1. FEV1%pred is plotted as a function of uLTE4 for patients in which uLTE4 is ≥ 3 SD above the mean reference value for normal patients [19]. Both FEV1%pred and uLTE4 data were collected at week 24 of the study. Hash mark denotes zero suppression on the y-axis. r = −.508, p=.002.
cea12076-sup-0002-FigS2.tifimage/tif1114KFigure S2. Asthma Control Scores by ALOX5 Promoter Genotype. Mean values for the Asthma Control Questionnaire (ACQ) are presented by ALOX5 promoter genotype (rs59439148) with error bars denoting 95% confidence limits. The Juniper ACQ score is plotted by genotype in all patients (white bars), in African American patients (light gray bars) and in White patients (dark gray bars). None of the White participants had x/x genotype. ACQ score data were collected at week 24 of the study. **Represents 2-tailed t-test comparing all patients with at least one wildtype allele versus all patients with two mutant alleles, p-value=0.09.
cea12076-sup-0003-FigS3.tifimage/tif197KFigure S3. Representative Genotypes for the ALOX5 Promoter Repeat Polymorphism. The genotypes of 5 representative study subjects is shown. Genotypes were assigned based on the size of the fragments (given in parentheses) and indicate the number of tandem Sp1 repeats. Individuals with only one peak are homozygous for that allele.
cea12076-sup-0004-TableS1.docxWord document14KTable S1. ALOX5 promoter polymorphisms, 5-LO expression, inflammation and clinical phenotype.
cea12076-sup-AppendixS1.docxWord document46KAppendix S1. American Lung Association Asthma Clinical Research Centers.

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