Conception via in vitro fertilization and delivery by Caesarean section are associated with paediatric asthma incidence
Article first published online: 20 AUG 2013
© 2013 John Wiley & Sons Ltd
Clinical & Experimental Allergy
Volume 43, Issue 9, pages 1058–1066, September 2013
How to Cite
Clinical & Experimental Allergy, 2013; (43) 1058–1066., , , , , , .
- Issue published online: 20 AUG 2013
- Article first published online: 20 AUG 2013
- Accepted manuscript online: 5 JUN 2013 10:45AM EST
- Manuscript Accepted: 2 JUN 2013
- Manuscript Revised: 27 APR 2013
- Manuscript Received: 21 JAN 2013
- cesarean section;
The association between perinatal factors and asthma inception is under rigorous investigation. Nevertheless, evidence of a correlation between asthma, conception via in vitro fertilization (IVF) and delivery through Caesarean section (C-section) is inconclusive.
We aimed to assess the relation of asthma incidence with IVF and C-section, after controlling for several potential confounding factors.
Parent-reported wheeze in the last 12 months (current), wheeze ever, physician-diagnosed asthma, method of conception, and type of delivery were recorded from questionnaires filled in by the parents of 2016 Greek children aged 9–13, (the Healthy Growth Study population). Some perinatal data were recorded from children's medical records and others were reported by parents; anthropometric measurements were also conducted in children.
IVF was correlated with physician-diagnosed asthma (OR = 2.25; 95% CI = 1.11–4.56), but not with current/ever wheeze after adjustment for potential confounding factors. After adjustment, C-section was also associated with asthma (OR = 1.39; 95% CI = 1.04–1.87), but not with current/ever wheeze. When the association of both IVF and C-section with asthma was examined in the same multivariate logistic regression model, it was weakened to borderline significance (OR = 2.04; 95% CI = 1–4.15 and OR = 1.34; 95% CI = 1–1.81 respectively).
Conclusions and Clinical Relevance
Conception via IVF and delivery by C-section may predispose children to future asthma development. Either variable could also exert a confounding effect on the link of the other to asthma; this may partially be accountable for inconsistencies in the findings of pertinent studies.