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Data S1. Materials and methods.

Figure S1. Linkage disequilibrium plot of the VEGFA gene region in the Hapmap CEU population.

Figure S2. Data from the CEU Hapmap population (release 22)

Figure S3. Association between single nucleotide polymorphisms and FVC at 6 years of age.

Figure S4. Association between single nucleotide polymorphisms and FEV0.5 at 1 month of age.

Figure S5. Association between single nucleotide polymorphisms and FEF50 at 1 month of age.

Figure S6. Association between single nucleotide polymorphisms and PD15 at 1 month of age.

Figure S7. Association between single nucleotide polymorphisms and recurrent troublesome lung symptoms at 18 months of age.

Figure S8. Association between single nucleotide polymorphisms and asthma at age 6–7.

Figure S9. Kaplan–Meier plot of the risk for asthma stratified on rs833052 genotypes.

Figure S10. Kaplan–Meier plot of the risk for asthma stratified on rs699947 genotypes.

Figure S11. Kaplan–Meier plot of the risk for asthma stratified on rs6900017 genotypes.

Table S1. Genotype distributions in the COPSAC cohort.

Table S2. Analysis of main outcomes and top three SNPs in three different linear regression analyses: overall (A), stratified for asthma (B) and adding asthma*SNP as interaction term to the overall analysis (C).

Table S3. Analysis of main outcomes and top three SNPs in three different linear regression analysis: overall (A), adjusted for smoking exposure (B) and adding smoking exposure*SNP as interaction term to the overall analysis (C).

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