Low gut microbiota diversity in early infancy precedes asthma at school age
Article first published online: 24 MAY 2014
© 2013 John Wiley & Sons Ltd
Clinical & Experimental Allergy
Volume 44, Issue 6, pages 842–850, June 2014
How to Cite
Clinical & Experimental Allergy, 2014 (44) 842–850., , , , , ,
- Issue published online: 24 MAY 2014
- Article first published online: 24 MAY 2014
- Accepted manuscript online: 11 DEC 2013 10:45AM EST
- Manuscript Accepted: 4 DEC 2013
- Manuscript Revised: 2 NOV 2013
- Manuscript Received: 15 SEP 2013
- BioGaia AB
- Ekhaga Foundation
- Heart and Lung Foundation
- Research Council for the South-East Sweden. Grant Number: F2000-106
- Olle Engqvist Foundation
- Swedish Asthma and Allergy Association
- Swedish Research Council
- University Hospital of Linköping
- Söderberg Foundation
- Vårdal Foundation for Health Care Science and Allergy Research, Sweden
- allergic rhinoconjunctivitis;
- hygiene hypothesis;
- molecular microbiology
Low total diversity of the gut microbiota during the first year of life is associated with allergic diseases in infancy, but little is known how early microbial diversity is related to allergic disease later in school age.
To assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to the prevalence of different allergic diseases in school age, such as asthma, allergic rhinoconjunctivitis (ARC) and eczema.
The microbial diversity and composition was analysed with barcoded 16S rDNA 454 pyrosequencing in stool samples at 1 week, 1 month and 12 months of age in 47 infants which were subsequently assessed for allergic disease and skin prick test reactivity at 7 years of age (ClinicalTrials.gov ID NCT01285830).
Children developing asthma (n = 8) had a lower diversity of the total microbiota than non-asthmatic children at 1 week (P = 0.04) and 1 month (P = 0.003) of age, whereas allergic rhinoconjunctivitis (n = 13), eczema (n = 12) and positive skin prick reactivity (n = 14) at 7 years of age did not associate with the gut microbiota diversity. Neither was asthma associated with the microbiota composition later in infancy (at 12 months). Children having IgE-associated eczema in infancy and subsequently developing asthma had lower microbial diversity than those that did not. There were no significant differences, however, in relative abundance of bacterial phyla and genera between children with or without allergic disease.
Conclusion and Clinical Relevance
Low total diversity of the gut microbiota during the first month of life was associated with asthma but not ARC in children at 7 years of age. Measures affecting microbial colonization of the infant during the first month of life may impact asthma development in childhood.