Impaired ICOSL in human myeloid dendritic cells promotes Th2 responses in patients with allergic rhinitis and asthma
Article first published online: 24 MAY 2014
© 2014 John Wiley & Sons Ltd
Clinical & Experimental Allergy
Volume 44, Issue 6, pages 831–841, June 2014
How to Cite
Clinical & Experimental Allergy, 2014 (44) 831–841., , , and ,
Key points: This study shows an impaired ICOSL expression by human myeloid dendritic cells, which contributes to biased Th2 polarization in allergic rhinitis.
- Issue published online: 24 MAY 2014
- Article first published online: 24 MAY 2014
- Accepted manuscript online: 24 MAR 2014 05:22PM EST
- Manuscript Accepted: 27 FEB 2014
- Manuscript Revised: 25 FEB 2014
- Manuscript Received: 15 OCT 2013
- FRSM. Grant Numbers: 3.4512.12, 3.4.565.06–3.4522.12
- National de la Recherche Scientifique
- GSK research grant
Figure S1. Analysis of purified myeloid DCs and T cells.
Figure S2. Expression of ICOSL and PD-L1 in freshly isolated and in cultured mDCs.
Figure S3. mDC viability in culture, upon LPS stimulation.
Figure S4. Expression of B7 co-stimulatory molecules in LPS-activated mDCs.
Figure S5. Expression of ILT3, ILT4 and OX40L in mDCs from allergic rhinitis patients and controls.
Figure S6. Expression of ICOSL and PD-L1 in LPS-activated mDCs.
Figure S7. Cytokine production in co-cultures at different mDC and CD4+ T cell ratios.
Figure S8. Cytokine production by LPS-activated mDCs.
Figure S9. Expression of ICOSL and PD-L1 of mDCs in presence of TSLP.
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