The regulatory T cells induction by epicutaneous immunotherapy is sustained and mediates long-term protection from eosinophilic disorders in peanut-sensitized mice
Article first published online: 24 MAY 2014
© 2014 DBV Technologies. Clinical & Experimental Allergy published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Clinical & Experimental Allergy
Volume 44, Issue 6, pages 867–881, June 2014
How to Cite
Clinical & Experimental Allergy, 2014 (44) 867–881., , , , , , ,
- Issue published online: 24 MAY 2014
- Article first published online: 24 MAY 2014
- Accepted manuscript online: 25 MAR 2014 11:37AM EST
- Manuscript Accepted: 12 MAR 2014
- Manuscript Revised: 1 MAR 2014
- Manuscript Received: 22 APR 2013
- DBV Technologies
- 1Mechanisms of immunotherapy to aeroallergens. Clin Exp Allergy 2011; 41:1235–46., .
- 2Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen. Clin Exp Allergy 1997; 27:1007–15., , et al.
- 3House dust mite immunotherapy results in a decrease in Der p 2-specific IFN-gamma and IL-4 expression by circulating T lymphocytes. Clin Exp Allergy 1997; 27:46–51., , , .
- 4Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation. J Allergy Clin Immunol 2007; 120:707–13., , , , , .
- 5IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003; 33:1205–14., , et al.
- 6Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells. Clin Exp Allergy 2010; 40:598–606., , et al.
- 7Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004; 199:1567–75., , et al.
- 8Increase of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis. Clin Immunol 2011; 139:65–74., , et al.
- 9Cow's milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity. J Allergy Clin Immunol 2010; 125:1165–7., , , , , .
- 10Epicutaneous immunotherapy results in rapid allergen uptake by dendritic cells through intact skin and downregulates the allergen-specific response in sensitized mice. J Immunol 2011; 186:5629–37., , et al.
- 11Epicutaneous immunotherapy (EPIT) blocks the allergic esophago-gastro-enteropathy induced by sustained oral exposure to peanuts in sensitized mice. PLoS ONE 2012; 7:e31967., , et al.
- 12Epicutaneous immunotherapy on intact skin using a new delivery system in a murine model of allergy. Clin Exp Allergy 2010; 40:659–67., , , , , .
- 13Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts. Int Arch Allergy Immunol 2011; 154:299–309., , , , , .
- 14Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity. J Allergy Clin Immunol 2008; 121:1120–5. e2., , et al.
- 15Birch pollen immunotherapy leads to differential induction of regulatory T cells and delayed helper T cell immune deviation. J Immunol 2010; 184:2194–203., , , , , .
- 16Immunological mechanisms of allergen-specific immunotherapy. Allergy 2011; 66:725–32., .
- 17Development and function of naturally occurring CD4+CD25+ regulatory T cells. J Leukoc Biol 2006; 80:458–70., .
- 18IL-10-producing type 1 regulatory T cells and allergy. Cell Mol Immunol 2007; 4:269–75., , , .
- 19Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 2009;123: 735–46; quiz 47–8., .
- 20Main-tenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 2007; 8:277–84., .
- 21Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function. J Allergy Clin Immunol 2008; 121:1460–6, 1466.e1–7., , , , , .
- 22FOXP3, IL-10, and TGF-beta genes expression in children with IgE-dependent food allergy. J Clin Immunol 2011; 31:205–15., , , , , .
- 23Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med 2004; 199:1679–88., , .
- 24Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol 2009; 123:43–52.e7., , , , .
- 25Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy. J Allergy Clin Immunol 2010; 125:1077–83.e8., , et al.
- 26Combined T regulatory cell and Th2 expression profile identifies children with cow's milk allergy. Clin Immunol 2010; 136:16–20., , et al.
- 27CD4+CD25+ T cells regulate the intensity of hypersensitivity responses to peanut, but are not decisive in the induction of oral sensitization. Clin Exp Allergy 2007; 37:572–81., , et al.
- 28Regulatory T cells control type I food allergy to Beta-lactoglobulin in mice. Int Arch Allergy Immunol 2011; 156:387–96., , et al.
- 29Expansion of circulating Foxp3+ D25bright CD4+ T cells during specific venom immunotherapy. Clin Exp Allergy 2008; 38:291–7., , et al.
- 30Ultra-rush venom immunotherapy induces differential T cell activation and regulatory patterns according to the severity of allergy. Clin Exp Allergy 2006; 36:704–13., , , , .
- 31Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009; 124:292–300, 300.e1–97., , et al.
- 32CD4+CD25+Foxp3+ T regulatory cells are not involved in oral desensitization. Int J Immunopathol Pharmacol 2010; 23:359–61., , , , , .
- 33Specific immunotherapy to birch allergen does not enhance suppression of Th2 cells by CD4(+)CD25(+) regulatory T cells during pollen season. J Clin Immunol 2009; 29:752–60., , , , .
- 34Induction of IL-10-producing regulatory T cells with TCR diversity by epitope-specific immunotherapy in pollinosis. J Allergy Clin Immunol 2009; 124:842–5.e7., , et al.
- 35Phenotypic and functional differences between human CD4+CD25+ and type 1 regulatory T cells. Curr Top Microbiol Immunol 2005; 293:303–26., .
- 36Functional analysis of birch pollen allergen Bet v 1-specific regulatory T cells. J Immunol 2007; 178:1189–98., , et al.
- 37Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4+ T cells. J Allergy Clin Immunol 2008; 122:603–9. e5., , et al.
- 38CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization. J Immunol 2005; 174:174–9., , et al.
- 39Antigen-non-specific regulation centered on CD25+Foxp3+ Treg cells. Cell Mol Immunol 2010; 7:414–8., , , .
- 40CD4+ T cells migrate into inflamed skin only if they express ligands for E- and P-selectin. J Immunol 1998; 161:963–70., , et al.
- 41Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med 2007; 204:1335–47., , et al.
- 42Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J Clin Invest 2010; 120:883–93., , et al.
- 43Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 2006; 108:4260–7., , et al.
- 44Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med 2004; 199:303–13., , et al.