Allergic sensitization and filaggrin variants predispose to the comorbidity of eczema, asthma, and rhinitis: results from the Isle of Wight birth cohort
Article first published online: 21 AUG 2014
© 2014 John Wiley & Sons Ltd
Clinical & Experimental Allergy
Volume 44, Issue 9, pages 1170–1178, September 2014
How to Cite
Clinical & Experimental Allergy, 2014 (44) 1170–1178., , , , , and ,
- Issue published online: 21 AUG 2014
- Article first published online: 21 AUG 2014
- Accepted manuscript online: 8 APR 2014 01:40AM EST
- Manuscript Accepted: 26 MAR 2014
- Manuscript Revised: 25 FEB 2014
- Manuscript Received: 28 AUG 2013
- National Institute of Health. Grant Numbers: R01 HL082925, R01AI091905
- allergic sensitization;
- filaggrin variants;
Allergic sensitization and filaggrin gene (FLG) variants are important risk factors for allergic disorders; however, knowledge on their individual and interactive effects on the coexistence of eczema, asthma, and rhinitis is lacking.
This study aimed at investigating the single and combined effects of allergic sensitization and FLG variants on the development of single and multiple allergic disorders.
The Isle of Wight birth cohort (n = 1456) has been examined at 1, 2, 4, 10, and 18 years of age. Repeated measurements of eczema, asthma, rhinitis, and skin prick tests were available for all follow-ups. FLG variants were genotyped in 1150 participants. Associations of allergic sensitization and FLG variants with single and multiple allergic disorders were tested in log-binomial regression analysis.
The prevalence of eczema-, asthma-, and rhinitis-only ranged from 5.6% to 8.5%, 4.9% to 10.2%, and 2.5% to 20.4%, respectively, during the first 18 years of life. The coexistence of allergic disorders is common, with approximately 2% of the population reporting the comorbidity of ‘eczema, asthma, and rhinitis’ during the study period. In repeated measurement analyses, allergic sensitization and FLG variants, when analysed separately, were associated with having single and multiple allergic disorders. Of particular significance, their combined effect increased the risk of ‘eczema and asthma’ (RR = 13.67, 95% CI: 7.35–25.42), ‘asthma and rhinitis’ (RR = 7.46, 95% CI: 5.07–10.98), and ‘eczema, asthma, and rhinitis’ (RR = 23.44, 95% CI: 12.27–44.78).
Conclusions and Clinical Relevance
The coexistence of allergic disorders is frequent, and allergic sensitization and FLG variants jointly increased risk of allergic comorbidities, which may represent more severe and complex clinical phenotypes. The interactive effect and the elevated proportion of allergic comorbidities associated with allergic sensitization and FLG variants emphasize their joint importance in the pathogenesis of allergic disorders.