Clinical & Experimental Allergy

Transfer of peanut IgE sensitisation after combined pancreas–kidney transplant

Authors


Correspondence:

Alalia Berry, Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.

E-mail: alalia.berry@hsc.utah.edu

Summary

Background

The transfer of peanut allergy has been reported following solid organ transplantation.

Objective

Present a case of peanut sensitization following combined pancreas-and-kidney transplantation.

Methods

Circulating specific IgE against peanut were measured in serum samples collected from the transplant recipient 1 month before transplantation, and 1, 3 and 6 months after transplantation. Skin tests were performed 1, 3 and 6 months following transplant.

Results

The organ recipient's pre-transplant peanut IgE levels were negative. At 1 month post-transplant, the patient had a 6 mm skin test to peanut and had serum IgE to peanut Arah1 of 0.79 kU/L. At 3 months, skin test size and IgE to peanut Arah1 decreased to 4 mm, and 0.69 kU/L respectively. At 6 months, the patient's skin test and IgE to peanuts were negative. At that time, the patient underwent a peanut food challenge without a clinical reaction to suggest allergy.

Conclusion and Clinical Relevance

We report the development of IgE peanut sensitization in a recipient of a combined pancreas and kidney transplantation. Increasing awareness of this allergen sensitization following transplantation may help prevent serious allergic reactions in transplant recipients.

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