Conflict of interest: This work was supported by Auriga International.
Assessment of the efficacy of a new formulation for plantar wart mummification: new experimental design and human papillomavirus identification
Article first published online: 18 DEC 2012
© The Author(s) CED © 2012 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 38, Issue 1, pages 85–88, January 2013
How to Cite
Viennet, C., Gheit, T., Muret, P., Aubin, F., Cabou, J., Marchal, A., Tommasino, M. and Humbert, P. (2013), Assessment of the efficacy of a new formulation for plantar wart mummification: new experimental design and human papillomavirus identification. Clinical and Experimental Dermatology, 38: 85–88. doi: 10.1111/ced.12025
- Issue published online: 18 DEC 2012
- Article first published online: 18 DEC 2012
- Manuscript Accepted: 7 JUN 2012
Cutaneous warts are caused by infection of the epidermis with human papillomavirus (HPV). Cryotherapy using liquid nitrogen is one of the most common local treatments. In this study, we used a novel ex vivo approach to compare the efficacy of a new product with conventional liquid-nitrogen cryotherapy by studying epidermal histology and assessing the presence of HPV types 1 and 2 DNA in plantar warts. The studied formulation, which acts by tissues mummification, is a combination of nitric acid, organic acids and metallic salts. We found that, similar to liquid nitrogen, the studied product induced alterations in the wart structure. In addition, unlike liquid nitrogen, this product also reduced the amount of HPV DNA. The results suggest that there is a poor correlation between the histological response and the antiviral efficacy of standard wart treatment.