Conflict of interest: none declared.
Experimental dermatology ● Original article
Genetic variants of the genes encoding zinc finger protein 313 and interleukin-13 confer a risk for psoriasis in a Chinese Uygur population
Version of Record online: 21 MAR 2013
© 2013 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 38, Issue 7, pages 768–774, October 2013
How to Cite
Feng, Y.-Y., Sun, L.-D., Zhang, C., Zuo, X.-B., Kang, X.-J., Wu, W.-D., Zhang, D.-Z., Buwajr, Dilinur, Wu, X.-J., Zhang, X.-J. and -m Pu, X. (2013), Genetic variants of the genes encoding zinc finger protein 313 and interleukin-13 confer a risk for psoriasis in a Chinese Uygur population. Clinical and Experimental Dermatology, 38: 768–774. doi: 10.1111/ced.12049
The first two authors contributed equally to this work and should be considered joint first authors.
- Issue online: 18 SEP 2013
- Version of Record online: 21 MAR 2013
- Manuscript Accepted: 27 JUL 2012
- key scientific and technological project of Xinjiang Uygur Autonomous Region. Grant Number: 200633129
- General Program of National Natural Science Foundation of China. Grant Numbers: 81072461, 30771196, 30800990
- Pre-project of State Key Basic Research Program 973. Grant Number: 2012CB722404
Recent work using genome–wide association studies (GWAS) in Chinese Han and white populations have discovered several novel psoriasis susceptibility genes.
To examine whether the risk loci for psoriasis identified in previous GWAS in a white population are also associated with psoriasis in a Chinese Uygur population in Xinjiang.
Genotyping analysis of eight single-nucleotide polymorphisms (SNPs) associated with psoriasis was performed for 539 patients with psoriasis and 749 controls, all of Chinese Uygur descent, using a commercial assay.
Two SNPs had an association with psoriasis in this Chinese Uygur population: SNP rs495337 in the gene encoding for zinc finger protein 313 (P < 0.001; OR = 0.80) and SNP rs20541 of the gene encoding for interleukin-13 (P < 0.001; OR = 0.82). In subgroup analyses, the two SNPs were significantly associated (P < 0.05) with type I psoriasis, Rs495337 showed statistically difference between positive family history of psoriasis patients and controls whereas rs20541 might preferentially associated with negative family history psoriasis patients. Interestingly, using multifactor dimensionality reduction, a significant two-locus interaction was seen between rs495337 and rs20541, with a crossvalidation consistency of 4/5 and average balanced prediction (accuracy 55.5%, P < 0.001).
ZNF313 and IL-13 are associated with risk for psoriasis in a Chinese Uygur population, and there is an effect of interaction between the two genes on this risk.