Conflict of interest: none declared.
Clinical dermatology ● Concise Report
Hypopigmented keratosis: is it a hyperkeratotic variant of idiopathic guttate hypomelanosis?
Article first published online: 20 APR 2013
© 2013 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 38, Issue 5, pages 526–529, July 2013
How to Cite
Kim, S. K., Park, J.-Y., Hann, S.-K., Kim, Y. C., Lee, E.-S. and Kang, H. Y. (2013), Hypopigmented keratosis: is it a hyperkeratotic variant of idiopathic guttate hypomelanosis?. Clinical and Experimental Dermatology, 38: 526–529. doi: 10.1111/ced.12057
- Issue published online: 18 JUN 2013
- Article first published online: 20 APR 2013
- Manuscript Accepted: 30 AUG 2012
- Korean Health Technology R & D project
- Ministry for Health, Welfare & Family Affairs, Korea. Grant Number: A100179
- Korean Science and Engineering Foundation (KOSEF)
- the Korean government (MOST). Grant Number: R13-2003–019
We have occasionally seen patients with acquired well-demarcated, scattered hypopigmented papules. In this study, we investigated the clinical and histopathological characteristics of such lesions. Biopsies were taken from the lesional and perilesional normal skin from 10 of 13 patients, which were compared with 10 idiopathic guttate hypomelanosis (IGH) samples. The lesions were scattered, well-circumscribed, flat-topped, hypopigmented papules. There was no age or gender predilection. Marked hyperkeratosis was present, with clear-cut margins distinguishable from the adjacent normal epidermis. The melanin content was decreased in the lesional epidermis, which was associated with a decrease in expression of melanogenesis-associated markers such as tyrosinase and NKI/beteb (marker of gp100) and reduction in the number of melanocytes. These histological findings were similar to those of IGH except for the additional finding of a thicker stratum corneum in this case seem to represent a ‘hyperkeratotic’ variant of IGH.