Conflict of interest: none declared.
Clinical dermatology ● Original article
Expression of gastrin-releasing peptide receptor in patients with cutaneous malignant melanoma
Article first published online: 12 APR 2013
© 2013 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 38, Issue 7, pages 707–712, October 2013
How to Cite
Marrone, B. F., Meurer, L., Moretto, A., Kleina, W. and Schwartsmann, G. (2013), Expression of gastrin-releasing peptide receptor in patients with cutaneous malignant melanoma. Clinical and Experimental Dermatology, 38: 707–712. doi: 10.1111/ced.12058
- Issue published online: 18 SEP 2013
- Article first published online: 12 APR 2013
- Manuscript Accepted: 22 AUG 2012
Gastrin-releasing peptide (GRP) is a neuroendocrine peptide shown to possess growth-stimulatory effects in many types of human cancers. High levels of GRP receptors have been found in various types of human cancers, and preclinical studies exploring the therapeutic use of GRP receptor (GRPR) antagonists have been reported, with promising results. Data on GRPR expression in human malignant melanoma (MM) are scanty.
To determine GRPR expression in biopsy material obtained from patients diagnosed with cutaneous MM.
Immunohistochemistry was performed on formalin–fixed, paraffin wax-embedded tissue samples obtained from 51 patients with cutaneous MM. The relationship between GRPR expression and the clinicopathological features was analysed using the Fisher exact test.
GRPR immunoexpression was found in 42/51 cutaneous melanoma samples (82.4%). It was strongly expressed in 30 cases (58.9%). There was no significant difference in the levels of GRPR expression between primary or metastatic lesions. We correlated the GRPR expression score with pathological features associated with prognosis in cutaneous MM. There was no significant difference in GRPR expression in relation to Clark level (CL; P = 0.35) or Breslow Index (BI; P = 0.17).
GRPR expression levels were high in tissue specimens of MM (82.4%), but did not correlate with pathological features related to prognosis, such as CL or BI. Further studies, preferably in a larger patient population, are warranted.