Conflict of interest: none declared.
Experimental dermatology ● Concise report
Effects of Y27632 on keratinocyte procurement and wound healing
Article first published online: 16 MAY 2013
© 2013 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 38, Issue 7, pages 782–786, October 2013
How to Cite
Gandham, V. D., Maddala, R. L., Rao, V., Jin, J. Y., Epstein, D. L., Hall, R. P. and Zhang, J. Y. (2013), Effects of Y27632 on keratinocyte procurement and wound healing. Clinical and Experimental Dermatology, 38: 782–786. doi: 10.1111/ced.12067
- Issue published online: 18 SEP 2013
- Article first published online: 16 MAY 2013
- Manuscript Accepted: 22 AUG 2012
A number of Rho-kinase inhibitors have been developed for various clinical applications. We examined the effects of the Rho-kinase inhibitor Y27632 on keratinocyte proliferation and migration, and found that it promoted primary human keratinocyte proliferation and migration in both monolayer and skin explant cultures. In addition, topical application of Y27632 enhanced cutaneous wound closure in the majority of wounds in mice. The growth and migration effects of Y27632 appeared to be specific to keratinocytes compared with dermal fibroblasts, and required intact Jun kinase function. Y27632 seems to be a promising agent for keratinocyte procurement and wounding healing.