The first two authors contributed equally to this work and should be considered joint first authors
Experimental Dermatology ● Concise report
Serum IgE levels are increased in patients with generalized pustular psoriasis
Article first published online: 18 JUN 2013
© 2013 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 38, Issue 5, pages 549–552, July 2013
How to Cite
Ding, Y., Yi, X. and Yu, N. (2013), Serum IgE levels are increased in patients with generalized pustular psoriasis. Clinical and Experimental Dermatology, 38: 549–552. doi: 10.1111/ced.12086
Conflict of interest: none declared.
- Issue published online: 18 JUN 2013
- Article first published online: 18 JUN 2013
- Manuscript Accepted: 15 OCT 2012
- Health Bureau of Shanghai City
Psoriasis is characterized by a T-helper (Th)1/Th17 immune response, and an increase in IgE levels is a prototypical marker of Th2 immunity. The aim of this retrospective case–control study was to analyse serum total IgE levels in generalized pustular psoriasis (GPP), a rare and severe variant of psoriasis. The levels of IgE in patients with GPP and patients with psoriasis vulgaris (PV) were compared with those of healthy controls. IgE levels were also compared with the levels of C-reactive protein (CRP), an indicator of systemic inflammation. The percentage of patients with GPP who had increased IgE levels was significantly higher than that of patients with PV and of healthy controls. The mean levels of IgE were also higher in the GPP group. The IgE levels in patients with GPP had a significant positive correlation with CRP levels. We hypothesize that serum IgE level is a general indicator for increased inflammation in GPP and PV.