Angiotensin-converting enzyme gene polymorphisms and the risk of psoriasis: a meta-analysis


  • Conflict of interest: none declared.

Correspondence: Dr Lechun Lu, Department of Physiology, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, Yunnan, 650500, China




The gene coding for angiotensin-converting enzyme (ACE) has been reported to be associated with the development of psoriasis.


To evaluate the association of psoriasis risk and ACE polymorphisms.


We carried out a retrieval of studies that explored associations between ACE polymorphism and psoriasis, and analysed the genotype frequencies.


In total, 8 studies with 1242 patients and 1646 controls were included. The genotype frequencies in all studies were in Hardy–Weinberg equilibrium. After pooling all studies, the results indicated that the I/I genotype was associated with risk of psoriasis (OR = 1.41, 95% CI 1.11–1.80, = 0.005), whereas the I/D genotype may decrease the risk of psoriasis (OR = 0.71, 95% CI 0.56–0.90, = 0.005) in Asian, but not in white populations.


Our study suggests that ACE polymorphism are associated with the risk of psoriasis in Asians, especially the I/I genotype and I allele. Further studies are needed to confirm our results.