Conflict of interest: none declared.
Clinical dermatology ● Original article
Angiotensin-converting enzyme gene polymorphisms and the risk of psoriasis: a meta-analysis
Article first published online: 23 APR 2013
© The Author(s) CED © 2013 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 38, Issue 4, pages 352–359, June 2013
How to Cite
Liu, T., Han, Y. and Lu, L. (2013), Angiotensin-converting enzyme gene polymorphisms and the risk of psoriasis: a meta-analysis. Clinical and Experimental Dermatology, 38: 352–359. doi: 10.1111/ced.12106
- Issue published online: 23 APR 2013
- Article first published online: 23 APR 2013
- Manuscript Accepted: 6 NOV 2012
The gene coding for angiotensin-converting enzyme (ACE) has been reported to be associated with the development of psoriasis.
To evaluate the association of psoriasis risk and ACE polymorphisms.
We carried out a retrieval of studies that explored associations between ACE polymorphism and psoriasis, and analysed the genotype frequencies.
In total, 8 studies with 1242 patients and 1646 controls were included. The genotype frequencies in all studies were in Hardy–Weinberg equilibrium. After pooling all studies, the results indicated that the I/I genotype was associated with risk of psoriasis (OR = 1.41, 95% CI 1.11–1.80, P = 0.005), whereas the I/D genotype may decrease the risk of psoriasis (OR = 0.71, 95% CI 0.56–0.90, P = 0.005) in Asian, but not in white populations.
Our study suggests that ACE polymorphism are associated with the risk of psoriasis in Asians, especially the I/I genotype and I allele. Further studies are needed to confirm our results.