Conflict of interest: none declared.
Clinical dermatology ● Concise report
Long-term successful healing of ulcerated necrobiosis lipoidica after topical therapy with becaplermin
Article first published online: 21 AUG 2013
© 2013 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 38, Issue 7, pages 745–747, October 2013
How to Cite
Tauveron, V., Rosen, A., Khashoggi, M., Abdallah-Lotf, M. and Machet, L. (2013), Long-term successful healing of ulcerated necrobiosis lipoidica after topical therapy with becaplermin. Clinical and Experimental Dermatology, 38: 745–747. doi: 10.1111/ced.12123
- Issue published online: 18 SEP 2013
- Article first published online: 21 AUG 2013
- Manuscript Accepted: 3 OCT 2012
We report a case of chronic leg ulceration occurring in a patient with necrobiosis lipoidica (NL). After many topical treatments had failed to achieve healing, treatment with topical becaplermin was started, which resulted in rapid improvement and ultimately complete healing of the ulceration. Treatment of ulcerated NL is often disappointing. Many topical and systemic drugs have been tried. Becaplermin is a platelet-derived growth factor indicated for the treatment of neuropathic diabetic ulcers measuring < 50 mm in size. To our knowledge, this is only the second case reported in the literature of ulcerated NL successfully treated with becaplermin.