Conflict of interest: none declared.
Clinical dermatology ● Original article
Association of the tumour necrosis factor-α polymorphisms rs361525 and rs1800629 with susceptibility to psoriasis: a meta-analysis
Article first published online: 20 NOV 2013
© 2013 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 38, Issue 8, pages 836–844, December 2013
How to Cite
Jia, Y., Qin, H. J., Zhang, J. X., Liu, X. L. and Li, L. J. (2013), Association of the tumour necrosis factor-α polymorphisms rs361525 and rs1800629 with susceptibility to psoriasis: a meta-analysis. Clinical and Experimental Dermatology, 38: 836–844. doi: 10.1111/ced.12136
The first two authors contributed equally to this work and should be considered joint first authors.
- Issue published online: 20 NOV 2013
- Article first published online: 20 NOV 2013
- Manuscript Accepted: 16 DEC 2012
Evidence has suggested that tumour necrosis factor (TNF)-α may be involved in the aetiology of psoriasis, but the underlying association of the TNF-α polymorphisms −238G/A (rs361525) and −308G/A (rs1800629) with the risk of psoriasis is still unconfirmed.
This meta-analysis was performed to determine whether the TNF-α −238G/A and −308G/A polymorphisms are associated with susceptibility to psoriasis.
Eligible studies were identified by searching PubMed, EMBASE, CNKI (China National Knowledge Infrastructure), CBM (Chinese biomedical literature database) and WANFANG databases within a range of published years from 1990 to August 2012. The odds ratio (OR) and 95% confidence interval (CI) were used to assess the different associations.
In total, 17 studies with 2847 cases and 2222 controls were found for −238G/A and 20 studies with 2975 cases and 2243 controls for −308G/A. The pooled results showed an overall increased risk of psoriasis for the −238G/A polymorphism (OR = 2.06, 95% CI = 1.45–2.94, P < 0.001 for AA/GA vs. GG) and a reduced psoriasis risk with the −308G/A polymorphism (OR = 0.68, 95% CI = 0.59–0.79, P < 0.001 for AA/GA vs. GG). This association was only present in early-onset psoriasis (OR = 3.68, 95% CI = 2.17–6.24, P < 0.001 for −238G/A; OR = 0.56, 95% CI = 0.43–0.72, P < 0.001 for −308G/A), whereas there was no association (OR = 0.98, 95% CI = 0.56–1.70, P = 0.92 for −238G/A) or a unreliable association (OR = 0.66, 95% CI = 0.46–0.94, P = 0.02 for −308G/A) in late-onset psoriasis.
This meta-analysis suggests that the TNF-α –238 and –308 promoter polymorphisms may play different roles in conferring susceptibility to psoriasis. Functional and well-designed studies should be conducted to confirm these results.