Conflict of interest: none declared.
Experimental dermatology ● Concise report
Nuclear and cytoplasmic localization of β-catenin in the nail-matrix cells and in an onychomatricoma
Article first published online: 20 NOV 2013
© 2013 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 38, Issue 8, pages 917–920, December 2013
How to Cite
Kim, C.-R., Shin, H.-T., Park, J.-H., Lee, D.-Y., Yang, J.-M., Kwon, G. Y., Jang, K.-T., Lee, K.-H. and Shim, J. S. (2013), Nuclear and cytoplasmic localization of β-catenin in the nail-matrix cells and in an onychomatricoma. Clinical and Experimental Dermatology, 38: 917–920. doi: 10.1111/ced.12139
- Issue published online: 20 NOV 2013
- Article first published online: 20 NOV 2013
- Manuscript Accepted: 3 DEC 2012
β-catenin plays an important role in hair morphogenesis. Previously, the nuclear and cytoplasmic localizations of β-catenin were identified in hair-matrix cells. To evaluate β-catenin expression in the nail matrix, we obtained human nail units. Immunohistochemistry for β-catenin was used to evaluate sections of normal nail units and of sections from a single case of onychomatricoma. In the nail unit, β-catenin was expressed in the nucleus and cytoplasm of the suprabasal nail-matrix cells. Of the other epithelial-cell types, only the cell membrane was β-catenin-positive. In the nail tissue from the onychomatricoma case, β-catenin was expressed in the nucleus and cytoplasm of the upper epithelial layers. Our result suggests that β-catenin plays an important role in nail formation. In addition, β-catenin expression in onychomatricoma supports the presence of nail-matrix cells in this condition. To our knowledge, this is the first report of β-catenin expression in the nucleus and cytoplasm of the nail matrix.