Conflict of interest: none declared.
Experimental dermatology ● Concise report
Influence of Th2 cells on hair cycle/growth after repeated cutaneous application of hapten
Article first published online: 22 NOV 2013
© 2013 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 39, Issue 2, pages 213–215, March 2014
How to Cite
Sugita, K., Nomura, T., Ikenouchi-Sugita, A., Ito, T., Nakamura, M., Miyachi, Y., Tokura, Y. and Kabashima, K. (2014), Influence of Th2 cells on hair cycle/growth after repeated cutaneous application of hapten. Clinical and Experimental Dermatology, 39: 213–215. doi: 10.1111/ced.12236
- Issue published online: 13 FEB 2014
- Article first published online: 22 NOV 2013
- Manuscript Accepted: 26 JUN 2013
Exposure to contact allergens in order to produce allergic contact dermatitis (ACD) seems to induce hair cycle/growth, but the mechanism of this remains unclear. In the current study, we investigated this mechanism and found that repeated application of hapten induced production of interleukin (IL)-4 in lymph-node immune cells. In addition, hair growth was induced in mice after the adoptive transfer of T-helper (Th)2 cells that had been purified from mice exposed to repeated cutaneous application of hapten. These findings lead us to speculate that Th2 cells that are repeatedly hapten-sensitized are recruited to hapten-challenged skin areas, and thus stimulate the production of IL-4 in the vicinity of the hair follicles, which influences hair cycle/growth. Our results may provide fundamental insights into the mechanism of contact hypersensitivity-induced hair cycle/growth.