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Intermediate cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis successfully treated with fluconazole

Authors

  • K. Daly,

    1. Fundación Jacinto Convit, Caracas, Venezuela
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  • H. De Lima,

    1. Division of Leishmaniasis, Instituto de Biomedicina, Caracas, Venezuela
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  • H. Kato,

    1. Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
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  • E. M. Sordillo,

    1. Department of Pathology and Laboratory Medicine and the Infectious Diseases Developmental Laboratory (Department of Medicine), St. Luke's Roosevelt Hospital Center, University Hospital of Columbia University College of Physicians and Surgeons, New York, NY, USA
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  • J. Convit,

    1. Laboratory of Biochemistry and Dermatopathology, Instituto de Biomedicina, UCV/MPPS/IVSS, Caracas, Venezuela
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  • O. Reyes-Jaimes,

    1. Laboratory of Biochemistry and Dermatopathology, Instituto de Biomedicina, UCV/MPPS/IVSS, Caracas, Venezuela
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  • O. Zerpa,

    1. Division of Leishmaniasis, Instituto de Biomedicina, Caracas, Venezuela
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  • A. E. Paniz-Mondolfi

    Corresponding author
    1. Fundación Jacinto Convit, Caracas, Venezuela
    2. Laboratory of Biochemistry and Dermatopathology, Instituto de Biomedicina, UCV/MPPS/IVSS, Caracas, Venezuela
    3. Medical Microbiology Laboratory, Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
    • Correspondence: Dr Alberto E. Paniz Mondolfi, Department of Microbiology, Yale University School of Medicine/Yale-New Haven Hospital, (PS656) 55 Park Street, New Haven CT 06511, USA

      E-mail: albertopanizm@gmail.com

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  • Conflict of interest: the authors declare that they have no conflicts of interest.

Summary

American cutaneous leishmaniasis is an endemic anthropozoonosis that exhibits a broad spectrum of clinical presentations. Intermediate/borderline disseminated cutaneous leishmaniasis is a distinct clinical condition that comprises cutaneous disease of a chronic nature, usually occurring as multiple lesions with or without mucosal involvement. The disease is usually caused by parasites of the subgenus Viannia, frequently occurs in context of an underlying disease, and is often resistant to standard antileishmanial therapy. We report a case that was refractory to standard therapy and other second-line drugs, but resolved after treatment with fluconazole, and review the use of fluconazole as a second-line drug in children.

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