• 1
    Caminero JA. Multidrug-resistant tuberculosis: epidemiology, risk factors and case finding. Int J Tuberc and Lung Dis 2010; 4:382390.
  • 2
    Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 global report on surveillance and response. WHO Global Report 2010, 71c.
  • 3
    Wright A, Zignol M, Van Deun A et al. Epidemiology of antituberculosis drug resistance 2002–07: an updated analysis of the global project on anti-tuberculosis drug resistance surveillance. Lancet 2009; 373:18611873.
  • 4
    Huang CT, Tsai YJ, Wu HD et al. Impact of non-tuberculous mycobacteria on pulmonary function decline in chronic obstructive pulmonary disease. Int J Tuberc Lung Dis 2012; 16:539545.
  • 5
    Winthrop KL, McNelley E, Kendall B et al. Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health disease. Am J Respir Crit Care Med 2010; 182:977982.
  • 6
    Lee W-I, Huang JL, Wei Yeh K et al. Immune defects in active mycobacterial diseases in patients with primary immunodeficiency diseases (PIDs). J Form Med Assoc 2011; 110:750758.
  • 7
    Demangel C, Garnier T, Rosenkrands I, Cole ST. Differential effects of prior exposure to environmental mycobacteria on vaccination with Mycobacterium bovis BCG or a recombinant BCG strain expressing RD1 antigens. Infect Immun 2005; 73:21902196.
  • 8
    Young SL, Slobbe L, Wilson R, Buddle BM, de Lisle GW, Buchan GS. Environmental strains of Mycobacterium avium interfere with immune responses associated with Mycobacterium bovis BCG vaccination. Infect Immun 2007; 75:28332840.
  • 9
    Flint JL, Kowalski JC, Karnati PK, Derbyshire KM. The RD1 virulence locus of Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatis. Proc Natl Acad Sci USA 2004; 101:1259812603.
  • 10
    Goletti D, Butera O, Bizzoni F, Casetti R, Girardi E, Poccia F. Region of difference 1 antigen-specific CD4+ memory T cells correlate with a favorable outcome of tuberculosis. J Infect Dis 2006; 194:984992.
  • 11
    Lee JS, Song CH, Kim CH et al. Profiles of IFN-gamma and its regulatory cytokines (IL-12, IL-18 and IL-10) in peripheral blood mononuclear cells from patients with multidrug-resistant tuberculosis. Clin Exp Immunol 2002; 128:516524.
  • 12
    Geffner L, Yokobori N, Basile J et al. Patients with multidrug-resistant tuberculosis display impaired Th1 responses and enhanced regulatory T-cell levels in response to an outbreak of multidrug-resistant Mycobacterium tuberculosis M and Ra strains. Infect Immun 2009; 77:50255034.
  • 13
    McDyer JF, Hackley MN, Walsh TE, Cook JL, Seder RA. Patients with multidrug-resistant tuberculosis with low CD4+ T cell counts have impaired Th1 responses. J Immunol 1997; 158:492500.
  • 14
    Churina EG, Urazova OI, Novitskiy VV. The role of Foxp3-expressing regulatory T cells and T helpers in immunopathogenesis of multidrug resistant pulmonary tuberculosis. Tuberc Res Treat 2012; 2012:19.
  • 15
    Chiacchio T, Casetti R, Butera O et al. Characterization of regulatory T cells identified as CD4(+) CD25(high) CD39(+) in patients with active tuberculosis. Clin Exp Immunol 2009; 156:463470.
  • 16
    Hall BM, Verma ND, Tran GT, Hodgkinson SJ. Distinct regulatory CD4+T cell subsets; differences between naïve and antigen specific T regulatory cells. Curr Opin Immunol 2011; 23:641647.
  • 17
    Sharma PK, Saha PK, Singh A, Sharma SK, Ghosh B, Mitra DK. FoxP3+ regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis. Am J Respir Crit Care Med 2009; 179:10611070.
  • 18
    Guyot-Revol V, Innes JA, Hackforth S, Hinks T, Lalvani A. Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis. Am J Respir Crit Care Med 2006; 173:803810.
  • 19
    Shang S, Gibbs S, Henao-Tamayo M, Shanley CA, McDonnell G et al. Increased virulence of an epidemic strain of Mycobacterium massiliense in mice. PLoS ONE 2011; 6:e24726. doi:10.1371/journal.pone.0024726.
  • 20
    Chimara E, Ferrazoli L, Ueky SY. Reliable identification of mycobacterial species by PCR-restriction enzyme analysis (PRA)-hsp65 in a reference laboratory and elaboration of a sequence-based extended algorithm of PRA-hsp65 patterns. BMC Microbiol 2008; 8:4856.
  • 21
    Fortes A, Pereira K, Antas PR et al. Detection of in vitro interferon-gamma and serum tumour necrosis factor-alpha in multidrug-resistant tuberculosis patients. Clin Exp Immunol 2005; 141:541548.
  • 22
    de Cassan SC, Pathan AA, Sander CR et al. Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A. Clin Vaccine Immunol 2010; 17:10661073.
  • 23
    Arend SM, Andersen P, van Meijgaarden KE et al. Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10. J Infect Dis 2000; 181:18501854.
  • 24
    Mazurek GH, LoBue PA, Daley CL et al. Comparison of a whole-blood interferon gamma assay with tuberculin skin testing for detecting latent Mycobacterium tuberculosis infection. JAMA 2001; 286:17401747.
  • 25
    Harboe M, Oettinger T, Wiker HG, Rosenkrands I, Andersen P. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect Immun 1996; 64:1622.
  • 26
    Arend SM, Thijsen SF, Leyten EM et al. Comparison of two interferon-gamma assays and tuberculin skin test for tracing tuberculosis contacts. Am J Respir Crit Care Med 2007; 175:618627.
  • 27
    Esmail H, Barry CE 3rd, Wilkinson RJ. Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies. Drug Discov Today 2012; 17:514521.
  • 28
    Lin MY, Reddy TB, Arend SM et al. Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria. Infect Immun 2009; 77:50715079.
  • 29
    Kwon YS, Kim EJ, Lee SH et al. Decreased cytokine production in patients with nontuberculous mycobacterial lung disease. Lung 2007; 185:337341.
  • 30
    Phillips R, Sarfo FS, Guenin-Macé L et al. Immunosuppressive signature of cutaneous Mycobacterium ulcerans infection in the peripheral blood of patients with Buruli ulcer disease. J Infect Dis 2009; 200:16751684.
  • 31
    Dheda K, Booth H, Huggett JF, Johnson MA, Zumla A, Rook GA. Lung remodeling in pulmonary tuberculosis. J Infect Dis 2005; 192:12011209.
  • 32
    Deveci F, Akbulut HH, Turgut T, Muz MH. Changes in serum cytokine levels in active tuberculosis with treatment. Mediat Inflamm 2005; 5:256262.
  • 33
    Dlugovitzky D, Torres-Morales A, Rateni L et al. Circulating profile of Th1 and Th2 cytokines in tuberculosis patients with different degrees of pulmonary involvement. FEMS Immunol Med Microbiol 1997; 18:203207.
  • 34
    Aung H, Wu M, Johnson JL, Hirsch CS, Toossi Z. Bioactivation of latent transforming growth factor beta1 by Mycobacterium tuberculosis in human mononuclear phagocytes. Scand J Immunol 2005; 61:558565.
  • 35
    Lim A, Allison C, Tan DB, Oliver B, Price P, Waterer G. Immunological markers of lung disease due to non-tuberculous mycobacteria. Dis Markers 2010; 29:103109.
  • 36
    Antas PR, Sampaio EP. Another round for the CD4+CD25+ regulatory T cells in patients with tuberculosis. Am J Respir Crit Care Med 2007; 176:214215.
  • 37
    Ryu YJ, Kim EJ, Lee SH et al. Impaired expression of Toll-like receptor 2 in nontuberculous mycobacterial lung disease. Eur Respir J 2007; 30:736742.
  • 38
    Vankayalapati R, Wizel B, Samten B et al. Cytokine profiles in immunocompetent persons infected with Mycobacterium avium complex. J Infect Dis 2001; 183:478484.
  • 39
    Greinert U, Schlaak M, Rüsch-Gerdes S, Flad HD, Ernst M. Low in vitro production of interferon-gamma and tumor necrosis factor-alpha in HIV seronegative patients with pulmonary disease caused by nontuberculous mycobacteria. J Clin Immunol 2000; 20:445452.
  • 40
    Chieppa M, Bianchi G, Doni A et al. Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program. J Immunol 2003; 171:45524560.
  • 41
    Lee JS, Song CH, Lim JH et al. The production of tumour necrosis factor-alpha is decreased in peripheral blood mononuclear cells from multidrug-resistant tuberculosis patients following stimulation with the 30-kDa antigen of Mycobacterium tuberculosis. Clin Exp Immunol 2003; 132:443449.
  • 42
    Murai M, Turovskaya O, Kim G et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol 2009; 10:11781184.
  • 43
    Urdahl KB, Shafiani S, Ernst JD. Initiation and regulation of T-cell responses in tuberculosis. Mucosal Immunol 2011; 4:288293.
  • 44
    Herzmann C, Ernst M, Ehlers S et al. Increased frequencies of pulmonary Treg cells in latent M. tuberculosis infection. Eur Respir J 2012. doi: 10.1183/09031936.00214611.
  • 45
    Toossi Z, Hirsch CS, Wu M et al. Distinct cytokine and regulatory T cells profile at pleural sites of dual HIV/tuberculosis infection compared to that in the systemic circulation. Clin Exp Immunol 2011; 163:333338.