Involvement of high mobility group box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome
Article first published online: 4 JUL 2013
© 2013 British Society for Immunology
Clinical & Experimental Immunology
Volume 173, Issue 2, pages 276–287, August 2013
How to Cite
Kudo, D., Toyama, M., Aoyagi, T., Akahori, Y., Yamamoto, H., Ishii, K., Kanno, E., Maruyama, R., Kaku, M., Kushimoto, S. and Kawakami, K. (2013), Involvement of high mobility group box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome. Clinical & Experimental Immunology, 173: 276–287. doi: 10.1111/cei.12106
- Issue published online: 4 JUL 2013
- Article first published online: 4 JUL 2013
- Accepted manuscript online: 27 MAR 2013 02:31AM EST
- Manuscript Accepted: 12 MAR 2013
- Ministry of Education, Culture, Sports, Science and Technology. Grant Number: 23659841
- Ministry of Health, Labor and Welfare of Japan. Grant Number: 22-SHINKOU-IPPAN-014
Fig. S1. Interleukin (IL)-1β and IL-6 production in the lungs of severe acute respiratory distress syndrome (ARDS) mice. Mice received intratracheal administration of lipopolysaccharide (LPS) or phosphate-buffered saline (PBS) 24 h after administration of α-galactosylceramide (α-GalCer) or 0·4% dimethylsulphoxide (DMSO)-containing phosphate-buffered saline (dPBS) via the same route. The IL-1-β and IL-6 concentrations in the bronchoalveolar lavage (BAL) fluids were measured at 0, 6, 12 and 24 h after treatment with LPS or PBS. The measurements in BAL fluids are normalized to the respective protein content. The data are shown as the median and interquartiles and each dot represents an individual mouse. *P < 0·05.
Table S1. Effect of recombinant thrombomodulin on interleukin (IL)-1β and IL-6 production in the lungs of severe acute respiratory distress syndrome (ARDS) mice.
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.