• 1
    Ghosh S, Hayden MS. New regulators of NF-[kappa]B in inflammation. Nat Rev Immunol 2008; 8:837848.
  • 2
    Hayden MS, Ghosh S. Shared principles in NF-κB signaling. Cell 2008; 132:344362.
  • 3
    Schreiber S, Nikolaus S, Hampe J. Activation of nuclear factor κB in inflammatory bowel disease. Gut 1998; 42:477484.
  • 4
    Wullaert A, Bonnet MC, Pasparakis M. NF-[kappa]B in the regulation of epithelial homeostasis and inflammation. Cell Res 2011; 21:146158.
  • 5
    Karrasch T, Kim J-S, Muhlbauer M, Magness ST, Jobin C. Gnotobiotic IL-10−/−; NF-κBEGFP mice reveal the critical role of TLR/NF-κB signaling in commensal bacteria-induced colitis. J Immunol 2007; 178:65226532.
  • 6
    Vereecke L, Sze M, Guire CM et al. Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis. J Exp Med 2010; 207:15131523.
  • 7
    Zhang J, Stirling B, Temmerman ST et al. Impaired regulation of NF-κB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. J Clin Invest 2006; 116:30423049.
  • 8
    Neurath MF, Pettersson S, Meyer Zum Buschenfelde K-H, Strober W. Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF-[kappa]B abrogates established experimental colitis in mice. Nat Med 1996; 2:9981004.
  • 9
    Nenci A, Becker C, Wullaert A et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 2007; 446:557561.
  • 10
    Steinbrecher KA, Harmel-Laws E, Sitcheran R, Baldwin AS. Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation. J Immunol 2008; 180:25882599.
  • 11
    Araki A, Kanai T, Ishikura T et al. MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis. J Gastroenterol 2005; 40:1623.
  • 12
    Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 2004; 118:229241.
  • 13
    Kerr LD, Duckett CS, Wamsley P et al. The proto-oncogene bcl-3 encodes an I kappa B protein. Genes Dev 1992; 6:23522363.
  • 14
    Nolan GP, Fujita T, Bhatia K et al. The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner. Mol Cell Biol 1993; 13:35573566.
  • 15
    Schwarz EM, Krimpenfort P, Berns A, Verma IM. Immunological defects in mice with a targeted disruption in Bcl-3. Genes Dev 1997; 11:187197.
  • 16
    Carmody RJ, Ruan Q, Palmer S, Hilliard B, Chen YH. Negative regulation of Toll-like receptor signaling by NF-κB p50 ubiquitination blockade. Science 2007; 317:675678.
  • 17
    Fransen K, Visschedijk MC, van Sommeren S et al. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. Hum Mol Genet 2010; 19:34823488.
  • 18
    Murphy CT, Moloney G, MacSharry J et al. Technical advance: function and efficacy of an α4-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis. J Leukoc Biol 2010; 88:12711278.
  • 19
    Cummins EP, Seeballuck F, Keely SJ et al. The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology 2008; 134:15665.e1.
  • 20
    Tambuwala MM, Cummins EP, Lenihan CR et al. Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. Gastroenterology 2010; 139:20932101.
  • 21
    Costello CM, Mah N, Häsler R et al. Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. PLoS Med 2005; 2:e199.
  • 22
    Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008; 29:947957.
  • 23
    Ota N, Wong K, Valdez PA et al. IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium. Nat Immunol 2011; 12:941948.
  • 24
    O'Connor JW, Kamanaka M, Booth CJ et al. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol 2009; 10:603609.
  • 25
    Dann SM, Spehlmann ME, Hammond DC et al. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol 2008; 180:68166826.
  • 26
    Tao Y, Drabik KA, Waypa TS et al. Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol 2006; 290:C10181030.
  • 27
    Kreisel D, Sugimoto S, Tietjens J et al. Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis. J Clin Invest 2011; 121:265276.