SEARCH

SEARCH BY CITATION

Keywords:

  • CD25;
  • FoxP3;
  • IL-10;
  • regulatory T cells;
  • SLE

Summary

The aim of this study was to examine the numbers of CD4+CD25forkhead box protein 3 (FoxP3)+, CD4+CD25+FoxP3+ and CD4+CXCR5+FoxP3+ T cells in patients with new-onset systemic lupus erythematosus (SLE). The numbers of CD4+CD25FoxP3+, CD4+CD25+FoxP3+ and CD4+CXCR5+FoxP3+ T cells and the concentrations of serum interleukin (IL)-10 in 23 patients and 20 healthy controls (HC) were measured. The potential correlations between CD4+FoxP3+ T cells, serum IL-10 and clinical measures in SLE patients were analysed. In comparison with that in the HC, significantly reduced numbers of CD4+CD25+FoxP3+ and CD4+CXCR5+FoxP3+ T cells, but increased numbers of CD4+CD25FoxP3+ T cells, were detected, accompanied by significantly lower levels of serum IL-10 in the patients. Stratification analysis indicated the numbers of CD4+CD25+FoxP3+ and CD4+CXCR5+FoxP3+ T cells and serum IL-10 levels in the patients with seropositive anti-dsDNA were significantly less than that in those with seronegative anti-dsDNA. Treatment with the anti-SLE therapy, particularly with prednisone, leflunomide and methotrexate, significantly improved the imbalance of these types of FoxP3+ T cells and increased the concentrations of serum IL-10 in the drug-responding patients. The numbers of CD4+CD25+FoxP3+ T cells were correlated negatively with the values of SLE disease activity index (SLEDAI), whereas the numbers of CD4+CD25FoxP3+ T cells were correlated positively with the values of SLEDAI, erythrocyte sedimentation rate (ESR) and serum C3. In addition, the concentrations of serum IL-10 were correlated positively with the numbers of CD4+CD25+FoxP3+ T cells, but negatively with the values of SLEDAI, serum C3, CRP and ESR in these patients. Our data indicate that the imbalance of different types of FoxP3+CD4+ T cells may contribute to the development of SLE in Chinese patients.