Joint senior authors.
How immunosuppressive therapy affects T cells from kidney transplanted patients of different age: the role of latent cytomegalovirus infection
Article first published online: 6 MAR 2014
© 2013 British Society for Immunology
Clinical & Experimental Immunology
Volume 176, Issue 1, pages 112–119, April 2014
How to Cite
Welzl, K., Weinberger, B., Kronbichler, A., Sturm, G., Kern, G., Mayer, G., Grubeck-Loebenstein, B. and Koppelstaetter, C. (2014), How immunosuppressive therapy affects T cells from kidney transplanted patients of different age: the role of latent cytomegalovirus infection. Clinical & Experimental Immunology, 176: 112–119. doi: 10.1111/cei.12205
- Issue published online: 6 MAR 2014
- Article first published online: 6 MAR 2014
- Accepted manuscript online: 13 SEP 2013 05:22AM EST
- Manuscript Accepted: 9 SEP 2013
- Pfizer Pharmaceutical Company and Novartis Pharmaceutical Company
- immunosuppressive therapy;
- T cells
The average age of patients receiving renal transplantation is increasing as programmes have been established which support the donation of organs from elderly donors to older recipients. Little is known about the effect of immunosuppressive therapy on the immune system of older patients. In this study, T cell function and the composition of the T cell repertoire were analysed in immunosuppressed renal transplant recipients of different age and cytomegalovirus (CMV) status in comparison to age- and CMV-matched controls. Independent of age and CMV status, the production of interleukin (IL)-2 and interferon (IFN)-γ by T cells was decreased in the patient groups and autologous serum from patients was capable of inhibiting the proliferation of CD3+ T cells. CXCR5 expression on T cells was increased in patients versus controls reflecting reduced endogenous IL-2 signalling under immunosuppressive therapy. In CMV-seronegative patients kidney transplantation and immunosuppressive therapy did not induce changes in the CD8+ T cell pool, but there was a moderate increase in CD4+CD28− effector T cells when compared to age-matched controls. In contrast, latent CMV infection triggered a shift from early to late differentiated CD4+ and CD8+ T cells in patients and controls. This shift was most pronounced in elderly transplant patients under immunosuppressive therapy. In conclusion, our results demonstrate that immunosuppressive therapy following kidney transplantation is effective in patients older than 65 years. Latent CMV infection, however, accelerates age-related changes in the T cell repertoire in elderly people under immunosuppressive therapy. These patients should therefore be monitored with special care.